Quantum AI nanotechnology, created by the Indian Institute of Technology, Indore (IIT-I), will aid in the precise and prompt identification of genetic alterations, particularly those linked to cancer.
The researchers overcame the long-standing drawbacks of conventional sequencing techniques by using cutting-edge AI algorithms to decipher the raw electric impulses with remarkable speed, accuracy, and cost-efficiency.
IIT-I said in a statement on Tuesday that the new technology, which aims to revolutionize unified DNA sequencing by combining explainable artificial intelligence (AI) with quantum transport, is expected to provide quick, high-resolution, and affordable natural, epigenetic, and artificial DNA sequencing.
Professor Biswarup Pathak and his research team, which includes Drs. Sneha Mittal and Milan Kumar Jena from IIT-I’s chemistry department, are in charge of the development.
Professor Pathak said, “This technology has transformative implications for genomics, personalised medicine, and cancer diagnostics, facilitating the early detection of genetic mutations and cancerous transformations. By enabling personalised treatment strategies and improving patient outcomes, this invention empowers researchers and clinicians with a powerful tool to decode genetic information across a broad spectrum of genomic contexts, marking a significant leap forward in DNA sequencing with unmatched precision and clarity.”
According to the institution, complex genomic variations, such as structural variants and changes that are essential for comprehending genetic illnesses and malignancies, are frequently missed by traditional sequencing techniques like Sanger sequencing and short-read next-generation sequencing (NGS).
IIT-I director Professor Suhas Joshi said, “These methods provide limited read lengths, which can miss important genomic information. The Quantum-AI nanotechnology with a solid-state nanopore/nanogap device has the potential to overcome this by providing high-resolution detection of nucleotides as they pass through the device, capturing unique electronic signatures that precisely identify genetic mutations.”
The approach allows for uniform sequencing throughout the genomes by measuring transverse tunneling electric readouts using solid nanopore/nanogap devices, according to the institution.
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